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Contributions of mathematical modeling to understanding whole-body vitamin A metabolism and to the assessment of vitamin A status

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Many biologists do not like to think about mathematics. However, mathematical modeling is essential in the biological and clinical sciences. For example, researchers rely on statistics to evaluate data, we all learned
Michaelis-Menten kinetics as students, and we generate standard curves to estimate the concentrations of unknowns in our samples. Additionally, in the vitamin A field, two other types of mathematical modeling are important. Mathematical modeling underlies the isotope dilution methods that are used to assess vitamin A status and the impact of vitamin A interventions (1, 2). Subjects are given a known amount of a nonradioactive
“tracer” of vitamin A  (e.g., a stable isotope), and the dilution of the dose in plasma is mathematically related to the size of the liver vitamin A store.

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Key Details

Year 2005
Authors Joanne Balmer Green
Language English
Keywords
DOI https://doi.org/10.52439/YOZO2914
DOI Number 10.52439/YOZO2914
ISBN
ISSN

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