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Conversion of Dietary Carotenoids and Vitamin A into Bioactive Retinoids: Exploring trails blazed by Jim Olson

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As readers of Sight and Life well know, vitamin A deficiency is one of the major micronutrient deficiencies worldwide and affects millions of children and women in the developing world.The widespread morbidity and mortality associated with the deficiency reflects the fact that the active forms of vitamin A (retinoids) are critical signaling molecules necessary in higher vertebrates for embryonic development, the regulation of gene transcription, visual transduction, immune function, and the control of metabolic processes. In spite of their importance in vertebrate development and physiology, the capability for the biosynthesis of molecules with retinoid activities is restricted to plants and microorganisms. Thus, animals, including humans, must obtain the essential vitamin A from the diet. Vitamin A activity in the diet comes from two sources: preformed vitamin A as retinyl esters in foods of animal origin, and provitamin A carotenoids, such as β-carotene, α-carotene, and β-cryptoxanthin,found in plant-derived foods. Indeed, in areas of the world with vitamin A deficiency, the major source of vitamin A is dietary carotenoids.

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Key Details

Year 2015
Authors Earl Harrison
Language English
Keywords
DOI https://doi.org/10.52439/CHBJ2746
DOI Number 10.52439/CHBJ2746
ISBN
ISSN

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