The addition of vitamin B12 (B12) to food fortification programs has been proposed in response to the high prevalence of B12 deficiency worldwide. In countries with implemented folic acid fortification programs, adding B12 is further suggested because of the interdependent metabolic roles offolate and B12 and to thereby address the potential for exacerbation of B12 deficiency symptoms associated with high folic acid intake. Comprehensive critical appraisals have discussed the lack of causal evidence proving the health benefits of low-dose B12 fortifacation (or supplementation) and ruling out potential for harm of high-dose B12 intake.1
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