Recognizing the complexity of decisions regarding the deployment of health interventions, many policy-setting bodies, including the World Health Organization (WHO), utilize GRADE (Grading of Recommendations Assessment, Development and Evaluation) frameworks. Such systematic and transparent frameworks consider the priority of the health problem, the certainty of the evidence of benefits or harms, and the costs and feasibility of the intervention compared with alternatives. When the evidence regarding antenatal multiple micronutrient supplementation (MMS) in low- and middle-income country (LMIC) settings is considered using such criteria, it is compelling that MMS should be recommended instead of only iron and folic acid (IFA) for supplementation in pregnancy.
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