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Summary of the conclusions of the WHO consultation

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Two large trials, coordinated and supported by WHO, were conducted in Zanzibar, Tanzania, and in Nepal to
evaluate the impact of zinc and/or iron-folic acid supplementation on the mortality and severe morbidity of
preschool children . In Zanzibar, an area of stable, perennial and intense transmission of Plasmodium falciparum malaria, routine iron-folic acid supplements given with or without zinc resulted in an increased rate of severe adverse events in children (morbidity and mortality). A concurrent substudy suggested that the adverse events occurred in supplemented children who were not iron deficient. In Nepal the trial showed no difference in mortality or the incidenceof the common infections between children receiving iron-folic acid with or without zinc, and those who received zinc alone or a placebo. The results from the study in Zanzibar, Tanzania raised the issue of the safety of administering additional iron to infants and young children in areas of malaria endemicity and its public health implications.

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Key Details

Year 2007
Authors Olivier Fontaine
Language English
Keywords
DOI https://doi.org/10.52439/UEQQ4458
DOI Number 10.52439/UEQQ4458
ISBN
ISSN

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