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The Importance of Vitamin A for the Development and Function of Lungs in Newborns

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Vitamin A is essential for the growth and development of cells and tissues. In its active form, retinoic acid (RA), it controls regular differentiation as a ligand for retinoic acid receptors (RAR, RXR).1,2 Vitamin A plays a substantial role in the respiratory epithelium and the lung. In the presence of moderate vitamin A deficiency the incidence of diseases of the respiratory tract is considerably increased. Repeated respiratory infections can be influenced therapeutically by moderate vitamin A supplementation.3,4,5 Besides its importance for lung function, vitamin A is also responsible for the development of many tissues and cells as well as for embryonic lung development. Recent studies have demonstrated that this occurs by various expressions of retinoid receptors, as well as by time-dependent changes of the vitamin A concentration in the tissue. Where maternal vitamin A is deficient fetal lung maturation might be seriously impaired, with consequences for postnatal function.

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Key Details

Year 2011
Authors Hans-Konrad Biesalski
Language English
Keywords
DOI https://doi.org/10.52439/MKSE6783
DOI Number 10.52439/MKSE6783
ISBN
ISSN

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