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The Role of Context

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We recently reported1 that maternal provision of a weekly equivalent of a recommended dietary allowance (RDA) of vitamin A, either preformed (7,000 μg retinol equivalents, RE ) or as β-carotene (42 mg, or ~7,000 μg RE), failed to reduce mortality related to pregnancy in a rural population in northern Bangladesh. This finding from the nearly seven year, ~60,000 pregnancy JiVitA- 1 Trial was unexpected, given endemic vitamin A deficiency,2 corroborated by reports of frequent night blindness during pregnancy,variable and seasonally low vitamin A intakes among rural women,4 and a high maternal mortality risk of ~575 per 100,000 live births.5,6 We expected these conditioning factors to lead to a result similar to that observed in the southern plains in Nepal in the mid-late 1990s, where continuous weekly supplementation with the same dosages of vitamin A or β-carotene, compared to a placebo (the NNIPS- 2 trial), led among ~20,100 pregnancies to a reduction of 44 % in mortality related to pregnancy.

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Key Details

Year 2011
Authors Keith P West Jr, George G. Graham
Language English
Keywords
DOI https://doi.org/10.52439/NEQP3753
DOI Number 10.52439/NEQP3753
ISBN
ISSN

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