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Sight and Life Newsletter 1/2006

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The red pigment lycopene, the most abundant carotenoid in tomatoes, is also found in lesser amounts in guava, pink grapefruit, papaya, and watermelon. Upon consumption, it accumulates in tissues including liver, adrenals, testes, and prostate. Lycopene is a 40 carbon atom, acyclic, open chain polyisoprenoid with 11 conjugated double bonds. All-trans lycopene is the predominant isomer found in plants, but cis isomers are the form most commonly found in human tissues suggesting preferential absorption of cis isomers. Nearly all men will develop some form of prostate cancer if they live long enough. With a 32% mortality rate, prostate cancer is the second most abundant cancer world-wide . North America and Australia, along with parts of South America and Europe, have the highest incidence rates of prostate cancer. Its occurrence is also high in parts of Africa, and Central America. North Africa and Eastern Asia have the lowest age standardized prostate cancer risk rate worldwide. Epidemiological studies suggest that increased intake of tomato products and higher blood levels of lycopene reduce risk of prostate cancer. Lycopene and tomatoes have been proposed to play a crucial role in the reduction of prostate cancer. This paper will review the composition of tomatoes and the epidemiological and experimental evidence regarding the association between lycopene and tomato consumption and prostate cancer risk. Finally, potential mechanisms of action and metabolites and oxidative products of lycopene will be discussed.

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Year 2006
Authors
Language English
Keywords
DOI https://doi.org/10.52439/NMXY1061
DOI Number 10.52439/NMXY1061
ISBN
ISSN

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